Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate → tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

HRID 69867

반응식

HRID 69867 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1)([O-])=O>CO>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH2:19]1

참가 물질

3

반응물 1

HCID 53426214Tert-butyl 4-(2-nitro-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate

생성물 1

HCID 53426177tert-Butyl 4-[2-amino-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Following the method of Example 49 (Method 2), tert-butyl 4-(2-nitro-4-(trifluoro-methyl)phenyl)piperazine-1-carboxylate in MeOH was reduced yielding tert-butyl 4-(2-amino-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate (99%). LCMS (m/z): 346.1 (MH+); LC Rt=3.38 min.

출처 및 근거

ORD 기록
ord-05943aaf658c44c99e7446df3ab7a65b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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