HCID 69046899, 화합물 → Tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamate

HRID 69873노트

반응식

HRID 69873 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:11]1)([O-])=O>C(O)C.C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH2:11]1

참가 물질

3

반응물 1

HCID 69046899HCID 69046899, 화합물

생성물 1

HCID 69095089Tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamate수율 79%

시약·촉매·용매 1

HCID 21584252Ethanol ethylacetate용매

실험 절차

The method of Example 90 (Method 5) was followed using 1 eq of tert-butyl 1-(4-nitropyridin-3-yl)piperidin-3-ylcarbamate in 1:1 ethanol/ethyl acetate at 30 psi for 72 hours, yielding tert-butyl 1-(4-aminopyridin-3-yl)piperidin-3-ylcarbamate (79%). LCMS (m/z): 293.1 (MH+); LC Rt=2.14 min.

후처리

  1. customfor 72 hours

출처 및 근거

ORD 기록
ord-05f5aac40ac24acda8ecad55c1e45bf8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

반응 노트

불러오는 중…