Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-6-bromopyrazine-2-carboxylic acid → Tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-benzoylphenyl)piperidin-4-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-6-bromopyrazine-2-carboxylic acid | HCID 18521600 | — |
| 반응물 | Tert-butyl 1-(2-amino-4-benzoylphenyl)piperidin-4-ylcarbamate | HCID 69043409 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-benzoylphenyl)piperidin-4-ylcarbamate | HCID 86669180 | 46% |
반응 단계
Following method 11, tert-butyl 1-(2-amino-4-benzoylphenyl)piperidin-4-ylcarbamate was coupled to 3-amino-6-bromopyrazine-2-carboxylic acid with TEA (1.5 eq) in ACN at 55° C. for 48 hours. Concentrated, triturated in cold ACN, filtered, and dried in vacuo yielding tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-benzoylphenyl)piperidin-4-ylcarbamate (46%). LCMS (m/z): 595.2 (MH+); LC Rt=3.94 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-1cc8fd21650641bdae0a96975df37264 |
| 출처 메모 | uspto-grants-2014_09 |