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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 69930생성일: 2026년 10월 25일

3-Amino-6-bromopicolinic acid → tert-butyl (3R,4R)-1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-yl-carbamate

https://huagongshe.com/reaction/69930

반응식

참여 물질

역할이름HCID투입량
반응물3-Amino-6-bromopicolinic acidHCID 45480452—
반응물tert-butyl (3R,4R)-1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamateHCID 58386806—
생성물tert-butyl (3R,4R)-1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-yl-carbamateHCID 8666920827%

반응 단계

Following Method 11 of Example 305, trans-(+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate and 3-amino-6-bromo-picolinic acid was reacted yielding trans-(+/−)-tert-butyl 1-(3-(3-amino-6-bromo-picolinamido)pyridin-4-yl)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate, (27%). LCMS (m/z): 621.2 (MH+); LC Rt=4.41 min.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08822497B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-ce42e1455aa94424bf615b2ed81b88b6
출처 메모uspto-grants-2014_09