참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | 2-Fluoro-5-methoxybenzoic acid | HCID 2774543 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Fluoro-5-hydroxybenzoic acid | HCID 2774480 | — |
반응 단계
To 2-fluoro-5-methoxybenzoic acid (5.00 g, 29.4 mmol) was added 49% aqueous HBr (50 mL) and glacial acetic acid (40 mL). The mixture was heated overnight at 140° C., cooled to RT, diluted with ice water and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated to yield 2-fluoro-5-hydroxybenzoic acid. MS m/z=157 [M+1]+. Calc'd for C7H5FO3: 156.11.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822514B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-0d749d0deff54f41803cec83004fd625 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
