1-Hydroxy-2-naphthoic acid → 1-Benzyloxy-naphthalene-2-carboxylic acid benzyl ester

참여 물질

역할	이름	HCID	투입량
반응물	1-Hydroxy-2-naphthoic acid	HCID 6844	—
반응물	Benzyl Chloride	HCID 7503	—
반응물	Potassium Carbonate	HCID 11430	—
용매	Dimethylformamide	HCID 6228	—
생성물	1-Benzyloxy-naphthalene-2-carboxylic acid benzyl ester	HCID 53944089	38.5%

반응 단계

K2CO3 (9.26 g, 67 mmol), dry DMF (20 mL), commercially available 1-hydroxy-2-naphthoic acid (1.88 g, 10 mmol), and benzyl chloride (5.6 mL). Yield: 1.41 g of yellow-orange viscous product (38.5% yield). Rf=0.38 (SiO2, 50% Hexanes/50% CH2Cl2). 1H NMR (400 MHz, CDCl3) δ 5.13 (s, 2H), δ 5.39 (s, 2H), δ 7.32-7.41 (m, 7H), δ 7.43-7.52 (m, 5H) δ 7.57 (d, J=7.8 Hz, 1H), δ 7.63 (d, J=8.7 Hz, 1H), δ 7.84 (d, J=8.2 Hz, 1H), δ 7.92 (d, J=8.7 Hz, 1H), δ 8.24 (d, J=8.2 Hz, 1H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08822515B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-1a41b11114574c4c95cc5760d85b314b
출처 메모	uspto-grants-2014_09