참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Chloro-6-methoxybenzothiazole | HCID 273132 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Chlorobenzo[d]thiazol-6-ol | HCID 14749843 | 81.2% |
반응 단계
Aluminum chloride (1.98 g, 14.9 mmol) was added to a solution of 6-methoxy-2-chlorobenzothiazole (1.06 g, 5.31 mmol) in toluene (40 mL), and the reaction mixture was heated to 110° C. After 1 h, the reaction mixture was allowed to cool to rt and 1 M aqueous HCl (40 mL) was added. The resulting precipitate was collected by filtration and washed with water (2×), saturated aqueous NaHCO3 (2×) and water (2×). The solid was air-dried, yielding 0.800 g (81%) of the title compound as a brown solid. LC-MS: RT=7.18 min., [M+H]+=185.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822472B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-0734884e56114ec8b0502d47934f5e90 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
