Dimethylformamide → tert-Butyl 4-((2-bromo-2,2-difluoroacetamido)methyl)-4-hydroxypiperidine-1-carboxylate

HRID 701454

반응식

[Br:17][C:18]([C:19](=[O:20])[O:21][CH2:22][CH3:23])([F:24])[F:25].[NH2:1][CH2:2][C:3]1([OH:16])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1.[O:26]=[CH:27][N:28]([CH3:29])[CH3:30]>>[NH:1]([CH2:2][C:3]1([OH:16])[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1)[C:19]([C:18]([Br:17])([F:24])[F:25])=[O:20]

참가 물질

반응물 3

HCID 6228Dimethylformamide

HCID 69585Ethyl bromodifluoroacetate

HCID 23396319tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

생성물 1

HCID 57988980tert-Butyl 4-((2-bromo-2,2-difluoroacetamido)methyl)-4-hydroxypiperidine-1-carboxylate

출처 및 근거

ORD 기록: ord-2ca80a0e537b46fd8a71b4115ed2c60a
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

연결된 노트

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