Ammonium Hydroxide → cis-2-Aminocyclohexanecarboxamide
반응식
C[O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C@@H:6]1[NH2:11])=O.[OH-].[NH4+:13]>C1(C)C=CC=CC=1>[NH2:11][C@H:6]1[CH2:7][CH2:8][CH2:9][CH2:10][C@H:5]1[C:3]([NH2:13])=[O:2]참가 물질
4
실험 절차
cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).
후처리
- concentrationThe reaction was concentrated to dryness in vacuo
- customazeotroped with toluene (50 mL)
- customThe crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification
출처 및 근거
- ORD 기록
- ord-fc1c3c23629140928ac9e042705804cc
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084178B2
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