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Diethyl Ether → alpha-(methoxyimino)-N,2-dimethyl-5-[1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]benzeneacetamide

HRID 70253
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HRID 70253 반응식
C[C:2]1[C:3]([CH3:30])=[C:4]([C:23](=[N:27][O:28][CH3:29])[C:24]([NH2:26])=[O:25])[CH:5]=[C:6]([C:8]2[CH:12]=[CH:11][N:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]=2)[CH:7]=1.CN.[CH2:33](OCC)C>O1CCCC1>[CH3:29][O:28][N:27]=[C:23]([C:4]1[CH:5]=[C:6]([C:8]2[CH:12]=[CH:11][N:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]=2)[CH:7]=[CH:2][C:3]=1[CH3:30])[C:24]([NH:26][CH3:33])=[O:25]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6329MethylamineHCID 86641520methyl alpha-(methoxyimino)-2-methyl-5-[1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]benzeneacetamide

생성물 1

HCID 86641519alpha-(methoxyimino)-N,2-dimethyl-5-[1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]benzeneacetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl α-(methoxyimino)-2-methyl-5-[1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]benzeneacetamide (i.e. the product of Example 13) (0.062 g, 0.149 mmol) in tetrahydrofuran (2 mL) under a nitrogen atmosphere was added methylamine (33% by weight in ethanol). The reaction mixture was stirred overnight at room temperature and then concentrated under reduced pressure to leave a solid. Hexanes and diethyl ether were added to the solid, and the mixture was filtered to obtain the tile compound, a compound of the present invention, as a white solid (56 mg).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customto leave a solid
  3. filtrationthe mixture was filtered
  4. customto obtain the tile compound

출처 및 근거

ORD 기록
ord-06d94a5202bb4f13b6e567db876c9943
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08822521B2

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