cis-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide → (1S,2S)-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

HRID 7028

반응식

HRID 7028 반응식
ClC1C=CC(S(N[C@H]2CCCC[C@@H]2C(O)=O)(=O)=O)=CC=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH:31][C@H:32]2[CH2:37][CH2:36][CH2:35][CH2:34][C@H:33]2[C:38]([NH2:40])=[O:39])(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH:31][C@H:32]2[CH2:37][CH2:36][CH2:35][CH2:34][C@@H:33]2[C:38]([NH2:40])=[O:39])(=[O:29])=[O:30])=[CH:24][CH:23]=1

참가 물질

3

반응물 2

HCID 69655699cis-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amideHCID 69656119(1S,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid

생성물 1

HCID 69656077(1S,2S)-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide수율 96%

실험 절차

(1S,2S)-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide was synthesized from (1S,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid (0.76 mmol) according to the method described for the preparation of (1R,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide. The crude product (230 mg) was obtained in 96% yield and carried into the next reaction without purification: 1H NMR (300 Mz, CDCl3) δ 7.72 (d, 2 H, J=8.4), 7.42 (d, 2 H, J=8.8), 3.23 (m, 1 H), 2.13 (m, 1 H), 1.85 (m, 1 H), 1.65 (m,3 H), 1.42 (m, 1 H), 1.13 (m, 3 H); MS m/e 339 (M+Na)+.

출처 및 근거

ORD 기록
ord-8edc0774097f4d56800f94b9e74b6e5c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084178B2

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