1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene → (1S,2R)-2-[(4-tert-Butyl-benzyl)-(4-chlorobenzenesulfonyl)-amino]-cyclohexanecarboxylic acid amide
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@@H:13]2[C:18]([NH2:20])=[O:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=1>>[C:29]([C:26]1[CH:25]=[CH:24][C:23]([CH2:22][N:11]([S:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)(=[O:9])=[O:10])[C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@@H:13]2[C:18]([NH2:20])=[O:19])=[CH:28][CH:27]=1)([CH3:32])([CH3:30])[CH3:31]참가 물질
3
실험 절차
The titled compound was prepared in 69% yield from (1S,2R)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide (75 mg, 0.237 mmol) and 1-bromomethyl-4-tert-butyl-benzene (57 mg, 0.249 mmol) according to the procedure described for Example 3: 1H NMR (500 Mz, DMSO) δ 7.58 (d, 2 H, J=8.9), 7.48 (d, 2 H, J=8.6), 7.38 (br s, 1 H), 7.18 (d, 2 H, J=8.2), 7.09 (d, 2 H, J=8.2), 6.76 (br, s, 1 H), 4.53 (ABq, 2 H, Δv=39.4, Jab=16.2), 3. 95 (dt, 1 H, Jd=12.8, Jt=4.0), 2.80 (m, 1 H), 1.79 (m, 1 H), 1.72 (m, 1 H), 1.63 (m, 1 H), 1.48 (m, 2 H), 1.33 (m, 2 H), 1.25 (s, 9 H), 1.18 (m, 2 H); MS m/e 485.3 (M+Na)+.