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Sodium Carbonate → 2-[[(4-ethoxy-3-methyl-2-pyridyl)methyl]thio]5,7-dihydro-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one

HRID 703156
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HRID 703156 반응식
[CH3:1][CH2:2][O-:3].[Na+].C(=O)([O-])[O-].[Na+].[Na+].[CH3:11][C:12]1([CH3:39])[C:23]2[C:15](=[CH:16][C:17]3[NH:18][C:19]([S:24][CH2:25][C:26]4[C:31]([CH3:32])=[C:30]([N+]([O-])=O)[CH:29]=[CH:28][N:27]=4)=[N:20][C:21]=3[CH:22]=2)[C:14]([CH3:37])([CH3:36])[C:13]1=[O:38]>C(O)C>[CH2:2]([O:3][C:30]1[CH:29]=[CH:28][N:27]=[C:26]([CH2:25][S:24][C:19]2[NH:18][C:17]3[CH:16]=[C:15]4[C:23](=[CH:22][C:21]=3[N:20]=2)[C:12]([CH3:11])([CH3:39])[C:13](=[O:38])[C:14]4([CH3:37])[CH3:36])[C:31]=1[CH3:32])[CH3:1]
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참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 2723922Sodium ethoxideHCID 221514395,7-dihydro-5,5,7,7-tetramethyl-2-[[(3-methyl-4-nitro-2-pyridyl)methyl]thio]indeno[5,6-d]imidazol-6(1H)-one

생성물 1

HCID 221514652-[[(4-ethoxy-3-methyl-2-pyridyl)methyl]thio]5,7-dihydro-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one

시약·촉매·용매 1

HCID 702Ethanol
용매

실험 절차

A mixture of 10.5 g of sodium ethylate. 20 g of sodium carbonate and 400 ml of ethanol was stirred at 50° under argon for 30 minutes and then treated with 7 g of 5,7-dihydro-5,5,7,7-tetramethyl-2-[[(3-methyl-4-nitro-2-pyridyl)methyl]thio]indeno[5,6-d]imidazol-6(lH)-one. After stirring at 50° for 5 hours under argon the reaction mixture was concentrated in vacuo. The residue was treated with methylene chloride and buffered by means of glacial acetic acid; the methylene chloride solution was extracted with sodium bicarbonate solution, dried and concentrated. The residue was chromatographed on silica gel while eluting with methylene chloride/ethyl acetate (3:1), the medium pressure flash chromatography method being used and the pressure being produced with nitrogen gas. There was obtained 2-[[(4-ethoxy-3-methyl-2-pyridyl)methyl]thio]5,7-dihydro-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(lH)-one which melts at 175-176° after recrystallization from ether.

후처리

  1. concentrationwas concentrated in vacuo
  2. additionThe residue was treated with methylene chloride
  3. extractionthe methylene chloride solution was extracted with sodium bicarbonate solution
  4. customdried
  5. concentrationconcentrated
  6. customThe residue was chromatographed on silica gel
  7. washwhile eluting with methylene chloride/ethyl acetate (3:1)
  8. customthe pressure being produced with nitrogen gas

출처 및 근거

ORD 기록
ord-1af94b54578d4df2997014bd9e9b50f5
출처 데이터셋
uspto-grants-1991_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04981861

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