Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propenenitrile, 3-hydroxy- → 3-(2,3-Dichlorophenacylamino)acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propenenitrile, 3-hydroxy- | HCID 3054073 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Ethanone, 2-amino-1-(2,3-dichlorophenyl)-, hydrochloride | HCID 22151845 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(2,3-Dichlorophenacylamino)acrylonitrile | HCID 67944094 | — |
반응 단계
2 g of 2,3-dichlorophenacylamine hydrochloride, 1 g of 3-hydroxyacrylonitrile, sodium salt, and 20 ml of ethanol are heated for 2 hours under reflux. The reaction mixture is concentrated by evaporation and the oily residue is purified by column chromatography (silica gel; elution with a 4:1 mixture of toluene/ethyl acetate), affording 3-(2,3-dichlorophenacylamino)acrylonitrile in the cis/trans ratio of 5:1. Melting point: 122°-125° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04981990 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-296fccb88ba5466da8ea50a16aeef931 |
| 출처 메모 | uspto-grants-1991_01 |