Nicardipine Hydrochloride → Nicardipine

HRID 703395

반응식

HRID 703395 반응식
[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][N:14]([CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH3:15])=[O:10])[CH:4]([C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N+:29]([O-:31])=[O:30])[CH:28]=2)[C:3]=1[C:32]([O:34][CH3:35])=[O:33].Cl.C(O)C.O.OCC(CO)O.C(OCC(CO)O)(=O)CCCCCCC/C=C\CCCCCCCC>>[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][N:14]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:15])=[O:10])[CH:4]([C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N+:29]([O-:31])=[O:30])[CH:28]=2)[C:3]=1[C:32]([O:34][CH3:35])=[O:33]

참가 물질

3

반응물 2

HCID 41114Nicardipine HydrochlorideHCID 131716747Ethanol water glycerin glycerol monooleate

생성물 1

HCID 4474Nicardipine

실험 절차

An L1 laminate is prepared as described in Example 1 using a polyisobutylene (PIB) adhesive in place of the silicone adhesive and a Daubert C-150 release liner in place of the Akrosil Biorelease release liner. A nicardipine-enhancer gel formulation is prepared by mixing adequate quantities of nicardipine HCl and Klucel HF® with a 65%/10%/20%/5% (volume percent) mixture of ethanol/ water/glycerine/glycerol monooleate to provide a final gel with a nicardipine concentration of 150 mg/cc and a Klucel level of 1.5% (wt/wt). A nicardipine transdermal system is then prepared as described in Example 1 using the nicardipine-enhancer gel formulation.

후처리

  1. customAn L1 laminate is prepared
  2. customA nicardipine-enhancer gel formulation is prepared

출처 및 근거

ORD 기록
ord-7d112dd6c27f4f21a9289903f9c8c19a
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983395

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