Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Quinuclidine, 3-amino-, dihydrochloride | HCID 197853 | — |
| 반응물 | N-(Aminocarbonyl)-2-thiophenecarboxamide | HCID 395032 | — |
| 반응물 | Maleate(2-) | HCID 5288227 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide | HCID 15616403 | — |
반응 단계
The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-thienoylurea (0.85 g, 5 mmol) and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.79 g) was converted to hydrochloride half hydrate, mp 232°-233° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04983600 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-f5c9b0a985694562aec02036d1803a0f |
| 출처 메모 | uspto-grants-1991_01 |