(3R)-1-Azabicyclo(2.2.2)octan-3-amine → HCID 15616382, 화합물

HRID 703426

반응식

HRID 703426 반응식
[NH2:1][C@@H:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[CH3:10][O:11][C:12]1[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=1[C:14]([N:16]=[C:17]=[O:18])=[O:15].C([O-])(=O)/C=C/C([O-])=O>>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[C@@H:2]([NH:1][C:17]([NH:16][C:14](=[O:15])[C:13]1[CH:19]=[CH:20][CH:21]=[CH:22][C:12]=1[O:11][CH3:10])=[O:18])[CH2:3]2

참가 물질

4

반응물 3

HCID 719215(3R)-1-Azabicyclo(2.2.2)octan-3-amineHCID 5460307FumarateHCID 141193282-Methoxybenzoyl isocyanate

생성물 1

HCID 15616382HCID 15616382, 화합물

실험 절차

The above compound was prepared, following the procedure of Example 1, from (R)-3-aminoquinuclidine (0.63 g, 5 mmol) and 2-methoxybenzoyl isocyanate (1.33 g, 7.5 mmol). The product (1.49 g) was converted to the 1:1 fumarate, mp 158°-159° C. (dec).

후처리

  1. customThe above compound was prepared

출처 및 근거

ORD 기록
ord-5b9a660eee2d4c4594b2b20a68ae6806
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983600

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