Sulfuric Acid → 2-(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid

HRID 703442노트

반응식

HRID 703442 반응식
C(O[C:5]([CH2:10][C:11](=[O:19])[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[CH:6][C:7]([OH:9])=[O:8])(=O)C.S(=O)(=O)(O)O>O>[O:19]=[C:11]1[CH:10]=[C:5]([CH2:6][C:7]([OH:9])=[O:8])[C:14]2[C:13](=[CH:18][CH:17]=[CH:16][CH:15]=2)[NH:12]1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 541950343-Acetyloxy-5-oxo-5-phenylamino-2-pentenoic acid

생성물 1

HCID 47377352-(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid수율 52.2%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

150 g (0.57 mol) of 3-acetyloxy-5-oxo-5-phenylamino-2-pentenoic acid are poured in small portions while stirring into 500 ml of 95-97% sulphuric acid, and the reaction medium is then heated to 100° C. for 2 h. After being cooled, this solution is poured into a mixture of 1 kg of ice and 500 ml of water while stirring. The solid thereby obtained is drained. It is washed with 3 times 100 ml of water and dried for 8 h at 60° C. 60.5 g (52%) of 2-oxo-1,2-dihydro-4-quinolineacetic acid, melting point 213°-215° C., are obtained.

후처리

  1. temperatureAfter being cooled
  2. customThe solid thereby obtained
  3. washIt is washed with 3 times 100 ml of water
  4. customdried for 8 h at 60° C

출처 및 근거

ORD 기록
ord-5dcc0b84346c4ec9880956a1e7b30d54
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983607

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