Diethyl Ether → HCID 13548560, 화합물

HRID 703443노트

반응식

HRID 703443 반응식
S(Cl)(Cl)=O.[O:5]=[C:6]1[CH:15]=[C:14]([CH2:16][C:17]([OH:19])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1.[CH3:20]COCC>CO>[O:5]=[C:6]1[CH:15]=[C:14]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 47377352-(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid

생성물 1

HCID 13548560HCID 13548560, 화합물수율 80%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

95 g (0.8 mol) of thionyl chloride are added dropwise in the course of approximately 1 h to a stirred suspension of 60 g (0.295 mol) of 2-oxo-1,2-dihydro-4-quinolineacetic acid in 1 1 of methanol. The mixture is left overnight. The solvent is driven off and the residue obtained is dissolved in 300 ml of boiling methanol. After the mixture is cooled, 300 ml of ether are added. The solid is drained and then recrystallized in methanol. 51.5 g (80%) of methyl 2-oxo-1,2-dihydro-4-quinolineacetate, melting point 209°-210° C., are obtained

후처리

  1. customthe residue obtained
  2. temperatureAfter the mixture is cooled
  3. customrecrystallized in methanol

출처 및 근거

ORD 기록
ord-06da27d9487f4fdfaa63a5c6f2454e5c
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983607

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