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Sodium Carbonate → 6-Chloro-N-(3-methyl-1H-indol-1-yl)-4-pyrimidinamine

HRID 703463
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반응식

HRID 703463 반응식
CN1CCCC1=O.[CH3:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([NH2:18])[CH:10]=1.[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1.C([O-])([O-])=O.[Na+].[Na+]>O>[Cl:19][C:20]1[N:21]=[CH:22][N:23]=[C:24]([NH:18][N:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]([CH3:8])=[CH:10]2)[CH:25]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 709434,6-DichloropyrimidineHCID 124272923-Methyl-1H-indol-1-amine

생성물 1

HCID 151582466-Chloro-N-(3-methyl-1H-indol-1-yl)-4-pyrimidinamine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

To 125 ml of 1-methyl-2-pyrrolidinone was added 3-methyl-1H-indol-1-amine (10.0 g), and this mixture was heated to 120° C. Then 4,6-dichloropyrimidine (10.43 g), was added to the hot solution and this mixture was stirred for four hours. The reaction was cooled, poured into water, basified with Na2CO3 (aq) extracted with ethyl acetate and the organic layer washed with water and dried (sat. NaCl, anhy. MgSO4).

후처리

  1. temperatureThe reaction was cooled
  2. extractionextracted with ethyl acetate
  3. washthe organic layer washed with water
  4. dry with materialdried (sat. NaCl

출처 및 근거

ORD 기록
ord-195fcca5cded465a953955017ceff35f
출처 데이터셋
uspto-grants-1991_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04983608

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