5-(4-Fluorophenyl)thiophene-2-carboxylic acid → 2-Cyano-N-[5-(4-(1,1-dimethylethyl)phenyl)thien-2-yl]-3-hydroxybut-2-enamide

HRID 703504노트

반응식

HRID 703504 반응식
[C:1]([C:3](=[C:19]([OH:21])[CH3:20])[C:4]([NH:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)=[O:5])#[N:2].C(C1S[C:27]([C:30]2[CH:35]=CC(F)=C[CH:31]=2)=CC=1)(O)=O>>[C:1]([C:3](=[C:19]([OH:21])[CH3:20])[C:4]([NH:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:30]([CH3:35])([CH3:31])[CH3:27])=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)=[O:5])#[N:2]

참가 물질

3

반응물 2

HCID 18734015-(4-Fluorophenyl)thiophene-2-carboxylic acidHCID 67868252HCID 67868252, 화합물

생성물 1

HCID 678696492-Cyano-N-[5-(4-(1,1-dimethylethyl)phenyl)thien-2-yl]-3-hydroxybut-2-enamide

실험 절차

2-Cyano-N-[5-(4-fluorophenyl)thien-2-yl]-3-hydroxybut-2-enamide, m.p. 232°-234° C. (from 2-carboxy-5-(4-fluorophenyl)thiophene).

출처 및 근거

ORD 기록
ord-3796423922af4b71abd4410acfc6a153
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983619

반응 노트

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