Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| 반응물 | 3-(chloromethyl)-5-nitro-1H-pyrazole | HCID 136175559 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline | HCID 136372389 | 49% |
반응 단계
(5-Nitro-1H-pyrazol-3-yl)methanol (524 mg, 3.66 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at 35° C. for 2 hrs. The solvent was removed to get a crude 3-(chloromethyl)-5-nitro-1H-pyrazole. Then following General Procedure A, the title compound (515 mg, 49%) was prepared from 2-amino-4-chlorobenzenethiol (161 mg, 1.01 mmol), crude 3-(chloromethyl)-5-nitro-1H-pyrazole, K2CO3 (468 mg, 3.39 mmol) in DMF (3 ml).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822530B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-a10a1cf7815243f2b4c580629e4fc303 |
| 출처 메모 | uspto-grants-2014_09 |