Thionyl Chloride → tert-butyl N-(4-(chloromethyl)pyridin-2-yl)carbamate

HRID 70361

반응식

HRID 70361 반응식
O[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:4]=1.O=S(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231510012-(Boc-amino)-4-(hydroxymethyl)pyridine

생성물 1

HCID 21068467tert-butyl N-(4-(chloromethyl)pyridin-2-yl)carbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-butyl (4-(hydroxymethyl)pyridin-2-yl)carbamate (600 mg, 2.679 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at rt for 2 hrs. The solvent was removed to get a crude tert-butyl (4-(chloromethyl)pyridin-2-yl)carbamate. Then following General Procedure A, the title compound (667 mg, 68%) was prepared from 2-amino-4-chlorobenzenethiol (641 mg, 4.019 mmol), K2CO3 (1.8 g, 13.39 mmol) in DMF (20 ml).

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-8f0ab008eb4043bd9a2383e29d6b05ca
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822530B2

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