Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Chloro-3-(trifluoromethyl)benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1-Chloro-2-(trifluoromethyl)benzene | HCID 6921 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 2-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 2736672 | — |
반응 단계
A solution of 0.6 mole of 2-chlorotrifluoromethylbenzene in 1 l of tetrahydrofuran is cooled to -65° C. and 0.58 mole of butyllithium dissolved in hexane is added. The mixture is maintained at the same temperature for 2 hours and a mixture containing 44 ml of dimethylformamide and 200 ml of tetrahydrofuran is then added dropwise. The reaction medium is allowed to return to ambient temperature, 600 ml of water are added, extraction is then carried out with ethyl ether followed by evaporation to dryness. The product is distilled to purify.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04983740 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-670b13ab1d164970a6e199b584e6fcfe |
| 출처 메모 | uspto-grants-1991_01 |