Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Ozone | HCID 24823 | — |
| 반응물 | methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoate | HCID 86743990 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 생성물 | methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate | HCID 86743989 | — |
반응 단계
A solution of 2.56 g of methyl (R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-6-heptenoate in 40 ml of ethyl acetate is treated with ozone at -75° C. After the reaction has finished 0.1 g of Pd-on-carbon is added thereto and the mixture is hydrogenated at room temperature. After the hydrogen uptake has finished one filters off the catalyst, washes with ethyl acetate and evaporates in vacuo. There is obtained crude methyl 5-formyl-(R)-3-[(tetrahydro-2H-pyran-2-yl)oxy]-pentanecarboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04983746 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-5d9d0b90eb424adb83865c33781a2d11 |
| 출처 메모 | uspto-grants-1991_01 |