Imidazole → HCID 54125133, 화합물

HRID 703690노트

반응식

HRID 703690 반응식
[OH:1][C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[C:19]([Si:23]([CH3:26])([CH3:25])Cl)([CH3:22])([CH3:21])[CH3:20].N1C=CN=C1.O>CN(C=O)C>[O:1]([C@@H:2]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:3][C:4]([O:6][CH3:7])=[O:5])[Si:23]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:26])[CH3:25]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 11021563(S)-Methyl 3-hydroxytetradecanoate

생성물 1

HCID 54125133HCID 54125133, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

12.9 g of methyl (S)-3-hydroxytetradecanoate are dissolved in 50 ml of DMF under argon 9.0 g of t-butyldimethylchlorosilane are added thereto, 8.5 g of imidazole are then added portionwise and the mixture is left to stir for 17 hours. The reaction mixture is poured into 300 ml of water and extracted three times with 50 ml of diethyl ether. The combined organic phases are dried, filtered and evaporated. By distillation at 140°-145° C./0.07 mm there is obtained methyl (S)-3-(t-butyldimethylsiloxy)tetradecanoate as a colourless oil.

후처리

  1. additionare added
  2. waitthe mixture is left
  3. extractionextracted three times with 50 ml of diethyl ether
  4. customThe combined organic phases are dried
  5. filtrationfiltered
  6. customevaporated
  7. distillationBy distillation at 140°-145° C./0.07 mm there

출처 및 근거

ORD 기록
ord-e69bdbfec3d94c208e29eeb7e1582426
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04983746

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