Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → ethyl N-(2,4,6-trimethylphenylacetyl)-piperidine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl piperidine-2-carboxylate | HCID 27517 | — |
| 반응물 | 2,4,6-Trimethylbenzeneacetyl chloride | HCID 11030754 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | ethyl N-(2,4,6-trimethylphenylacetyl)-piperidine-2-carboxylate | HCID 14883010 | 95.9% |
반응 단계
223 g (1.125 mol) of mesityleneacetyl chloride are added dropwise at 0° to 10° C. to 182 ml (1.157 mol) of ethyl pipecolinate and 162 ml (1.157 mol) of triethylamine in 1,200 ml of absolute tetrahydrofuran (THF), followed by stirring for 1 hour at room temperature. After the mixture has been stirred into 5 liters of ice water and 500 ml of 1 N HCl, the product is filtered off with suction, washed with water and dried in vacuo at 50° C. over P2O5. 342.3 g (95.2% of theory) of ethyl N-(2,4,6-trimethylphenylacetyl)-piperidine-2-carboxylate are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985063 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-193ecb6fe6c54afdaf079156e523890e |
| 출처 메모 | uspto-grants-1991_01 |