Methyl chloroacetate → Methyl 2-[3-(trifluoromethyl)anilino]acetate

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].Cl[CH2:13][C:14]([O:16][CH3:17])=[O:15].O.O.O.C([O-])(=O)C.[Na+]>>[CH3:17][O:16][C:14](=[O:15])[CH2:13][NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1

참가 물질

반응물 3

HCID 7295Methyl chloroacetate

HCID 73753-(Trifluoromethyl)aniline

HCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 251270Methyl 2-[3-(trifluoromethyl)anilino]acetate

실험 절차

3-Trifluoromethylaniline (80.5 g), methyl chloroacetate (44 ml) and sodium acetate trihydrate (114 g) were treated according to the method of Intermediate 1 to give a solid (84 g), a sample of which (ca. 1 g) was purified by FCC eluting with System A (1:1) to give a solid which was recrystallised from System A to give the title compound, m.p. 60°-63°.

출처 및 근거

ORD 기록: ord-d84c99f7928f4c7ea76bae5facbb8b2f
출처 데이터셋: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04985427

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