3-Propylaniline → HCID 19829931, 화합물

HRID 703808

반응식

HRID 703808 반응식
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+].Cl[CH2:17][C:18]([O:20][CH3:21])=[O:19]>CCOCC>[CH3:21][O:20][C:18](=[O:19])[CH2:17][NH:7][C:6]1[CH:8]=[CH:9][CH:10]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:5]=1

참가 물질

5

반응물 3

HCID 60563-PropylanilineHCID 7295Methyl chloroacetateHCID 516892Sodium Bicarbonate

생성물 1

HCID 19829931HCID 19829931, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 3-propylaniline (20 g), sodium bicarbonate (24.9 g) and methyl chloroacetate (24.0 g) were stirred under nitrogen at 80°-90° for 24 h. The cooled reaction mixture was poured into ether (100 ml) and filtered. The filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml), then dried and concentrated in vacuo. The oily product (21.2 g) was distilled to give the title compound as a liquid, b.p. 160° at 0.35 mmHg, which solidified to give a low melting solid (16.1 g).

후처리

  1. customThe cooled reaction mixture
  2. filtrationfiltered
  3. washThe filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml)
  4. customdried
  5. concentrationconcentrated in vacuo
  6. distillationThe oily product (21.2 g) was distilled

출처 및 근거

ORD 기록
ord-5ececdb4c7464b4fa84b2a2e2cfb8931
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985427

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