Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide → [1-(Naphth-2-ylmethyl)piperid-4-yl]urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide | HCID 72002 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | [1-(Naphth-2-ylmethyl)piperid-4-yl]urea | HCID 13145794 | — |
반응 단계
1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (prepared according to Example 1) is hydrolysed by refluxing in 2N sodium hydroxide to give [1-(naphth-2-ylmethyl)piperid-4-yl]urea (m.p. 183°-5° C.). The product is acylated by reaction with 4-methoxybenzoyl chloride to give the title compound, m.p. of HCl, quarterhydrate=193°-193.5° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985438 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-2c76d37b0dc245abbd2bee0e89cad040 |
| 출처 메모 | uspto-grants-1991_01 |