Boron trifluoride etherate → HCID 15617824, 화합물

HRID 703870노트

반응식

HRID 703870 반응식
B(F)(F)F.CCOCC.C([SiH](CC)CC)C.[CH2:17]([O:24][C:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][C:26]=1[CH:35](O)[C:36]#[C:37][CH2:38][CH2:39][CH2:40][C:41]([O:43][CH3:44])=[O:42])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl.CCOCC>[CH2:17]([O:24][C:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][C:26]=1[CH2:35][C:36]#[C:37][CH2:38][CH2:39][CH2:40][C:41]([O:43][CH3:44])=[O:42])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

7

반응물 4

HCID 8000Boron trifluoride etherateHCID 11430Potassium CarbonateHCID 12052TriethylsilaneHCID 15617823HCID 15617823, 화합물

생성물 1

HCID 15617824HCID 15617824, 화합물수율 50%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매2회

실험 절차

To a solution of boron trifluoride etherate (5.0 mL. 0.041 mole) in methylene chloride (150 mL) at 0°, triethylsilane (20 mL. 0.126 mole) was added, followed by a solution of methyl 7-(1-benzyloxy-2-naphthyl)-7-hydroxy-5-heptynoate (5.00 g, 0.013 mole) in methylene chloride (20 mL). The mixture was stirred for 30 minutes then poured into saturated aqueous potassium carbonate. The crude product was isolated by extraction with ether, and chromatographed with 1:1 ether/hexane. This provided the title compound (2.42 g, 50%) as an oil.

후처리

  1. customchromatographed with 1:1 ether/hexane

출처 및 근거

ORD 기록
ord-6e57bfc6969941d58196f4255e45bebd
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985442

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