1-Naphthol → 2-(4-Chlorobutyryl)-1-naphthol

HRID 703886

반응식

HRID 703886 반응식
[C:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][CH2:14][CH2:15][C:16](O)=[O:17].B(F)(F)F.CCOCC>O>[Cl:12][CH2:13][CH2:14][CH2:15][C:16]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1]=1[OH:11])=[O:17]

참가 물질

5

반응물 3

HCID 70051-NaphtholHCID 8000Boron trifluoride etherateHCID 123004-Chlorobutanoic acid

생성물 1

HCID 156179222-(4-Chlorobutyryl)-1-naphthol수율 38.2%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 1-naphthol (15.14 g, 0.105 mole), 4-chlorobutyric acid (9.90 mL, 0.100 mole), and boron trifluoride etherate (75 mL) was heated on a steam bath for 4 hours. The mixture was then treated slowly with 100 mL of water, and heating continued for 30 minutes. The mixture was poured into water, stirred, and the solution decanted. The residue was triturated with water, then crystallized from ethanol to provide the title compound (9.50 g, 38%) as a pale green solid, mp 73°-79°.

후처리

  1. temperaturewas heated on a steam bath for 4 hours
  2. temperatureheating
  3. customthe solution decanted
  4. customThe residue was triturated with water
  5. customcrystallized from ethanol

출처 및 근거

ORD 기록
ord-f6f70456936c498884c9c366de5ebcb0
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985442

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