2-Fluoro-4-nitroanisole → 3-Fluoro-4-methoxyaniline

HRID 703895

반응식

HRID 703895 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1)([O-])=O>O1CCOCC1.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1

참가 물질

4

반응물 1

HCID 2231042-Fluoro-4-nitroanisole

생성물 1

HCID 5811103-Fluoro-4-methoxyaniline수율 104.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매2회HCID 312751,4-Dioxane용매

실험 절차

[I] 2 g of 5% palladium carbon was added to a solution prepared by dissolving 10 g of 4-nitro-2-fluoroanisol in 150 ml of 1,4-dioxane, and the mixture was subjected to catalytic reduction under a hydrogen gas pressure of 4 kg/cm2 at room temperature for 30 minutes. After the completion of the reaction, palladium carbon was removed by filtration, and the solvent was distilled off under reduced pressure to obtain 8.6 g of 4-amino-2-fluoroanisol.

후처리

  1. customprepared
  2. customat room temperature
  3. customfor 30 minutes
  4. customwas removed by filtration
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-75e9e91173c2460e983b1c6c1afaf4e5
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985449

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