1,1,1-Trimethoxy-2-methylpropane → N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

HRID 704030노트

반응식

HRID 704030 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([S:13]([NH2:16])(=[O:15])=[O:14])[S:10][N:9]=1.[C:17](OC)(OC)([O:21][CH3:22])[CH:18]([CH3:20])[CH3:19]>CCCCCC>[CH3:22][O:21][C:17](=[N:16][S:13]([C:11]1[S:10][N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[N:12]=1)(=[O:15])=[O:14])[CH:18]([CH3:20])[CH3:19]

참가 물질

4

반응물 2

HCID 404951,1,1-Trimethoxy-2-methylpropaneHCID 141831333-(2-Methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

생성물 1

HCID 54509802N-(1-Methoxy-2-methylpropylidene)-3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A mixture of 3 g of 3-(2-methylphenyl)-1,2,4-thiadiazole-5-sulfonamide and 11 ml of trimethyl orthoisobutyrate was heated to reflux and stirred for 2 hours. The mixture was allowed to cool to room temperature, whereupon a precipitate formed. Hexane was added and the mixture was stirred for 15 minutes. The solid was filtered and washed with hexane and dried in vacuum (P2O5) to give 3.49 g of solid, m.p. 116°-118°.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. customformed
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe solid was filtered
  6. washwashed with hexane
  7. dry with materialdried in vacuum (P2O5)

출처 및 근거

ORD 기록
ord-6455b4f259a141abbf05e8610918c59f
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985450

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