4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)nitrobenzene → 4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline

HRID 704091노트

반응식

HRID 704091 반응식
[H][H].[Cl:3][C:4]1[C:9]([O:10][CH2:11][C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:13])=[CH:8][C:7]([N+:20]([O-])=O)=[C:6]([F:23])[CH:5]=1>[C].[Pd].C1(C)C=CC=CC=1>[Cl:3][C:4]1[C:9]([O:10][CH2:11][C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:13])=[CH:8][C:7]([NH2:20])=[C:6]([F:23])[CH:5]=1

참가 물질

5

반응물 2

HCID 146178494-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)nitrobenzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 146178504-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline수율 62.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 1140Toluene용매

실험 절차

Hydrogen gas (1.3 liters) was introduced into a mixture of the compound (III) (6.4 g), 5% palladium-carbon (0.32 g) and toluene (64 g) at room temperature while stirring in 1 hour. After removal of the catalyst from the reaction mixture, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography to give 4-chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline (3.6 g).

후처리

  1. customAfter removal of the catalyst from the reaction mixture
  2. customthe solvent was removed under reduced pressure
  3. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-656a2b2c6c0e4954967fca7975248aa6
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985570

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