Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Flumiclorac-pentyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Acetic acid, chloro-, pentyl ester | HCID 138488 | — |
| 반응물 | 1H-Isoindole-1,3(2H)-dione, 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydro- | HCID 158651 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Flumiclorac-pentyl | HCID 443048 | 41.9% |
반응 단계
To a solution of N-(4-chloro-2-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydrophthalimide (3 g) in dimethylformamide (100 ml), anhydrous potassium carbonate (0.8 g) and then amyl chloroacetate (1.9 g) were added, and the resultant mixture was heated at 70° to 80° C. for 3 hours. The reaction mixture was cooled to room temperature, admixed with water and extracted with diethyl ether. The etheral layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the compound (I) (1.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985570 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-c6457f195a754b8cae07436ba550202f |
| 출처 메모 | uspto-grants-1991_01 |