Acetic Acid → Flumiclorac-pentyl

HRID 704095

반응식

HRID 704095 반응식
[Cl:1][C:2]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:12])=[CH:7][C:5]([NH2:6])=[C:4]([F:19])[CH:3]=1.[C:20]([OH:23])(=O)[CH3:21]>O>[Cl:1][C:2]1[C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:12])=[CH:7][C:5]([N:6]2[C:20](=[O:23])[C:21]3[CH2:2][CH2:3][CH2:4][CH2:5][C:7]=3[C:8]2=[O:9])=[C:4]([F:19])[CH:3]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 146178504-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline

생성물 1

HCID 443048Flumiclorac-pentyl수율 175.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of the compound (II) (12.0 g), 3,4,5,6-tetarhydrophthalic anhydride (7.56 g) and acetic acid (50 g) was heated under reflux for 2 hours. The reaction mixture was cooled to room temperature, and water (75 g) was added thereto. The precipitated crystals were collected by filtration to give the compound (I) (15.4 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. filtrationThe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-ede6506e630c45878393723ffbf3599d
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985570

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