반응식
[N+:1]([CH3:4])([O-:3])=[O:2].Cl[CH2:6][CH2:7][CH2:8][C:9](=O)[CH2:10][CH2:11][CH2:12]Cl.[NH3:15].CO>>[N+:1]([CH2:4][C:9]12[CH2:10][CH2:11][CH2:12][N:15]1[CH2:6][CH2:7][CH2:8]2)([O-:3])=[O:2]참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
To a solution of nitromethane (0.67 g, 11 mmol) in 0.3 ml of 16% NH3 /MeOH, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 24 hours at 20° C. under ammonia gas atmosphere. The reaction mixture was concentrated and 0.1N NaOH was added to the residue to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.42 g of the desired compound (Yield: 90%).
후처리
- concentrationThe reaction mixture was concentrated
- addition0.1N NaOH was added to the residue
- extractionto extract with methylene chloride
- dry with materialThe extract was dried over anhydrous sodium sulfate
- concentrationconcentrated
- distillationdistilled in vacuo
출처 및 근거
- ORD 기록
- ord-f3023006ff74463695d8ee852d5a6d51
- 출처 데이터셋
- uspto-grants-1991_01
- 특허 번호
- US04985569
연결된 노트
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