Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 704102생성일: 2026년 10월 25일
7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine → (Hexahydro-1H-pyrrolizin-7A-YL)methanamine
https://huagongshe.com/reaction/704102
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine | HCID 10487359 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (Hexahydro-1H-pyrrolizin-7A-YL)methanamine | HCID 10654304 | 75% |
반응 단계
To a suspension of Raney nickel (300 mg) in 5.0 ml of ethanol, 7a-nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine (300 mg, 1.76 mmol, obtained in Example 1) was added and the resulting mixture was stirred for 1 hour at 20° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was concentrated, and the resulting crude product was distilled in vacuo to afford 185 mg of the desired compound (Yield: 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04985569 |
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| 출처 데이터셋 | uspto-grants-1991_01 |
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| ORD ID | ord-78612acd1ee047b1a1d64e394c2e893f |
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| 출처 메모 | uspto-grants-1991_01 |
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