Water → 2,2-Dimethyl-5-ethyl-5-hydroxymethyl-1,3-dioxane methylsulphonate

HRID 704128

반응식

HRID 704128 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][C:7]1([CH3:17])[O:12][CH2:11][C:10]([CH2:15][CH3:16])([CH2:13][OH:14])[CH2:9][O:8]1.O>N1C=CC=CC=1>[CH3:1][S:2]([OH:4])(=[O:8])=[O:3].[CH3:6][C:7]1([CH3:17])[O:8][CH2:9][C:10]([CH2:15][CH3:16])([CH2:13][OH:14])[CH2:11][O:12]1

참가 물질

5

반응물 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 118161521,3-Dioxane-5-methanol, 5-ethyl-2,2-dimethyl-

생성물 1

HCID 200755932,2-Dimethyl-5-ethyl-5-hydroxymethyl-1,3-dioxane methylsulphonate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulphonyl chloride (15 ml.) was added dropwise to a stirred solution of 2,2-dimethyl-5-ethyl-5-hydroxymethyl-1,3-dioxane 1 (33.0 g) in dry pyridine (100 ml.) at 0°. The mixture was stirred for two hours at room temperature and then poured into water. The aqueous mixture was extracted with ether. The ethereal extracts were washed with water, dried over anhydrous magnesium sulphate and evaporated in vacuo. 2,2-Dimethyl-5-ethyl-5-hydroxymethyl-1,3-dioxane methane sulphonate was obtained as a colourless oil (39 g.) which solidified on standing. The compound was used without further purification.

후처리

  1. extractionThe aqueous mixture was extracted with ether
  2. washThe ethereal extracts were washed with water
  3. dry with materialdried over anhydrous magnesium sulphate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-8084b5d0d46c477d9685028d329a148e
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04985582

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