Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclobutylmethylamine → N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclobutylmethylamine | HCID 409746 | — |
| 반응물 | 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride | HCID 20074886 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-cyclobutylmethyl-10-[(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 15096214 | 48.6% |
반응 단계
By working in a manner similar to that described below in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (3.4 g) in dichloromethane (100 cc) and with cyclobutylmethylamine (4.5 g), N-(cyclobutylmethyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.7 g) is obtained, after recrystallization in isopropyl ether, in the form of white crystals, m.p. 133° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985419 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-06a5e37eb5e34ec6b94a8ab08fc66f06 |
| 출처 메모 | uspto-grants-1991_01 |