Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Fumaric Acid → N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | N-(2-hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 20074856 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate | HCID 20074855 | 46.8% |
반응 단계
N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.86 g) is dissolved in boiling 2-propanol (22 cc). A solution of fumaric acid (0.47 g) in 2-propanol (18 cc) under reflux is added to this solution. After cooling, the crystals formed are washed with ethyl ether (2×10 cc), filtered and dried under reduced pressure (5 mm Hg; 0.67 kPa) at 50° C. N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate (1.09 g) is thereby obtained in the form of yellow crystals, m.p. about 80° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985419 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-f2e34afa41c24fd883f98e7f27bbb8f0 |
| 출처 메모 | uspto-grants-1991_01 |