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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 7043생성일: 2026년 10월 24일

4-(Bromomethyl)benzonitrile → trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amide

https://huagongshe.com/ko/reaction/7043

반응식

참여 물질

역할이름HCID투입량
반응물4-(Bromomethyl)benzonitrileHCID 86996—
반응물trans-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amideHCID 69656245—
생성물trans-2-[(4-Chlorobenzenesulfonyl)-(4-cyano-benzyl)-amino]-cyclohexanecarboxylic acid amideHCID 1124746843%

반응 단계

The titled compound was prepared in 43% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 4-bromomethyl-benzonitrile according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.71(m, 4 H), 7.53 (m, 4 H), 7.29 (s, 1 H), 6.76 (s, 1 H), 4.44 (AB2,2 H,Δv=16,Jab=84 Hz), 3.96 (m, 1 H), 1.80 (m, 1 H), 1.57 (m, 3 H), 1.17 (m, 5 H); MS m/e 432.01 (M+H)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07084178B2
출처 데이터셋uspto-grants-2006_08
ORD IDord-386f48eba40548c182cc938b1a8dd1e7
출처 메모uspto-grants-2006_08