Sodium Iodide → 1-(3-Iodopropyl)-4-methoxybenzene

HRID 704402

반응식

HRID 704402 반응식
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)(=O)=O.[I-:17].[Na+]>CC(C)=O>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][CH2:6][I:17])=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 116659383-(4-Methoxyphenyl)propyl methanesulfonate

생성물 1

HCID 140406651-(3-Iodopropyl)-4-methoxybenzene수율 93%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 6.30 g of 3-(4-methoxyphenyl)propyl methanesulfonate and 11.1 g of sodium iodide in 100 ml of acetone was refluxed for 15 hours. The reaction mixture was concentrated under reduced pressure and, after addition of water, the residue was extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 6.62 g of 3-(4-methoxyphenyl)propyl iodide.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionafter addition of water
  3. extractionthe residue was extracted with ether
  4. washThe organic layer was washed with saturated aqueous solution of sodium chloride
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-169f61b8947e4eea92bcc75a0d45316c
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04987132

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