Formaldehyde → 2-Methylisoindoline-5,6-diol

HRID 704460노트

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HRID 704460 반응식
Br.[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[OH:12])[CH2:8][NH:7][CH2:6]2.[CH:13]([O-])=O.[Na+].C=O.O>C(O)=O>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[OH:12])[CH2:8][N:7]([CH3:13])[CH2:6]2

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 962WaterHCID 2723810Sodium FormateHCID 200743492,3-dihydro-1H-isoindole-5,6-diol hydrobromide

생성물 1

HCID 140984212-Methylisoindoline-5,6-diol수율 72.3%

시약·촉매·용매 1

HCID 284Formic Acid용매

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온도
80 °C

실험 절차

15.39 g (66 mmol) of 5,6-dihydroxyisoindoline hydrobromide and 4.48 g (66 mmol) of sodium formate were dissolved in 100 ml of a 50% formic acid aqueous solution, and then 5.17 ml (70 mmol) of 37% formalin was added thereto. The mixture was stirred at 80° C. for 4 hours. Then, the solvent was distilled off under reduced pressure, and the residue was dissolved in 200 ml of water and subjected to active carbon treatment. The active carbon was filtered off, and the filtrate was stirred under cooling with ice, and adjusted to pH 8.0 with a saturated sodium hydrogen carbonate aqueous solution, and then it was stirred at the same temperature for about 30 minutes. The precipitates were collected, and washed with water to obtain yellowish green primary crystalline powder. This powder was combined with secondary crystalline powder obtained from the filtrate, and after an addition of 300 ml of water, stirred for 30 minutes. The insolubles was collected to obtain 7.87 g (yield: 72.3%) of the above identified compound.

후처리

  1. distillationThen, the solvent was distilled off under reduced pressure
  2. dissolutionthe residue was dissolved in 200 ml of water
  3. filtrationThe active carbon was filtered off
  4. stirringthe filtrate was stirred
  5. temperatureunder cooling with ice
  6. stirringit was stirred at the same temperature for about 30 minutes
  7. customThe precipitates were collected
  8. washwashed with water
  9. customto obtain yellowish green primary crystalline powder
  10. customobtained from the filtrate
  11. stirringstirred for 30 minutes
  12. customThe insolubles was collected
  13. customto obtain 7.87 g (yield: 72.3%) of the

출처 및 근거

ORD 기록
ord-491d917410ce44e6be8f6f3d218ebe8f
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04987235

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