Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride → 4-chloro-N-(5-chloro-2-{[3-oxo-3-(pyrrolidin-1-yl)propyl]sulfanyl}phenyl)-3-(trifluoromethyl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride | HCID 2780719 | — |
| 반응물 | 3-((2-Amino-4-chlorophenyl)thio)-1-(pyrrolidin-1-yl)propan-1-one | HCID 86690995 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-chloro-N-(5-chloro-2-{[3-oxo-3-(pyrrolidin-1-yl)propyl]sulfanyl}phenyl)-3-(trifluoromethyl)benzenesulfonamide | HCID 71738129 | 17.2% |
반응 단계
Following General Procedure B, the title compound (242 mg, 17%) was prepared from 3-((2-amino-4-chlorophenyl)thio)-1-(pyrrolidin-1-yl)propan-1-one (758 mg, 2.67 mmol) and 4-chloro-3-(trifluoromethyl)benzene-1-sulfonyl chloride (745 mg, 2.67 mmol) in pyridine (10 ml).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822530B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bf680a66a4b646c5a1b35aade4ad59ec |
| 출처 메모 | uspto-grants-2014_09 |