4-Amino-3-methylphenol hydrochloride (1:1) → 1-(4-Hydroxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo-[3,2-c]cinnoline hydrochloride

HRID 704576

반응식

HRID 704576 반응식
[Cl:1][CH2:2][CH2:3][C:4]1[N:5]=[N:6][C:7]2[C:12]([C:13]=1Cl)=[CH:11][CH:10]=[CH:9][C:8]=2[CH3:15].Cl.[OH:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[C:20]([CH3:25])[CH:19]=1>C(O)(C)C>[ClH:1].[OH:17][C:18]1[CH:24]=[CH:23][C:21]([N:22]2[C:13]3[C:12]4[CH:11]=[CH:10][CH:9]=[C:8]([CH3:15])[C:7]=4[N:6]=[N:5][C:4]=3[CH2:3][CH2:2]2)=[C:20]([CH3:25])[CH:19]=1

참가 물질

4

반응물 2

HCID 4592344-Amino-3-methylphenol hydrochloride (1:1)HCID 200727624-Chloro-3-(2-chloroethyl)-8-methylcinnoline

생성물 1

HCID 200727601-(4-Hydroxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo-[3,2-c]cinnoline hydrochloride

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

3-(2-Chloroethyl)-4-chloro-8-methylcinnoline (2 g, 0.0083 mol) and 4-hydroxy-2-methylaniline hydrochloride (1.32 g, 0.0083 mol) in isopropanol (50 ml) were heated under reflux in a nitrogen atmosphere for 20 hours. The solid obtained was collected by filtration and dried. Recrystallization from isopropanol/ethanolic HCl gave the title compound as a partial hydrate, 0.64 g, m.p. 292-294°.

후처리

  1. temperatureunder reflux in a nitrogen atmosphere for 20 hours
  2. customThe solid obtained
  3. filtrationwas collected by filtration
  4. customdried
  5. customRecrystallization from isopropanol/ethanolic HCl

출처 및 근거

ORD 기록
ord-7c1afd5036694aa8a5e45f726ac3f874
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988695

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