N1-[(5-methyl-2-furanyl)methyl]-1,2-benzenediamine → Ethyl 3-[[[[2-[[(5-methyl-2-furanyl)methyl]amino]phenyl]amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate

HRID 704705노트

반응식

HRID 704705 반응식
[N:1]([CH:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5]1)=[C:2]=[S:3].[CH3:14][C:15]1[O:19][C:18]([CH2:20][NH:21][C:22]2[C:23]([NH2:28])=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:17][CH:16]=1>O1CCCC1>[CH3:14][C:15]1[O:19][C:18]([CH2:20][NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[NH:28][C:2]([NH:1][CH:4]2[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5]2)=[S:3])=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 14182882N1-[(5-methyl-2-furanyl)methyl]-1,2-benzenediamineHCID 14575268Ethyl 3-isothiocyanatopyrrolidine-1-carboxylate

생성물 1

HCID 15037310Ethyl 3-[[[[2-[[(5-methyl-2-furanyl)methyl]amino]phenyl]amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 80 parts of ethyl 3-isothiocyanato-1-pyrrolidinecarboxylate, 88.8 parts of N1 -[(5-methyl-2-furanyl)methyl]-1,2-benzenediamine and 560 parts of tetrahydrofuran was stirred for 2 hours at reflux temperature. After cooling to room temperature, the reaction mixture was evaporated, yielding 144.9 parts (100%) of ethyl 3-[[[[2-[[(5-methyl-2-furanyl)methyl]amino]phenyl]amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate as a residue (interm. 7).

후처리

  1. temperatureat reflux temperature
  2. customthe reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-fe57936b56c343ee9c2a26f578ca01e4
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988689

반응 노트

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