참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | 1-Bromo-2-chlorobenzene | HCID 12754 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Phosphine, tris(4-methylphenyl)- | HCID 13956 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N'-(2-chlorophenyl)ethane-1,2-diamine | HCID 12666392 | 0% |
반응 단계
Ref: R2239 To a mixture of 1-bromo-2-chlorobenzene (0.824 g, 4.30 mmol), tri-p- tolylphosphine (0.262 g, 0.86 mmol), sodium 2-methylpropan-2-olate (0.414 g, 4.30 mmol), diacetoxypalladium (0.097 g, 0.43 mmol) in toluene (4 mL) was added ethane-1,2-diamine (1.293 g, 21.52 mmol). The mixture was heated with microwave at 140 °C for 1 h. No product was formed.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-5911a740f60145b0bc355f2a886b772f |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
