Potassium Carbonate → HCID 56952134, 화합물

HRID 705029노트

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HRID 705029 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[O:8][CH:9]=[CH:10][N:11]=2)[CH:2]=1.Br[C:13]1[N:18]=[C:17]([C:19]2[N:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[O:8][C:9]([C:13]3[N:18]=[C:17]([C:19]4[N:20]=[CH:21][CH:22]=[CH:23][N:24]=4)[CH:16]=[CH:15][CH:14]=3)=[CH:10][N:11]=2)[CH:2]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 158812582-(6-Bromopyridin-2-yl)pyrimidineHCID 204053873-(1,3-Oxazol-2-yl)pyridine

생성물 1

HCID 56952134HCID 56952134, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
120 °C

실험 절차

Under argon, 130 mg (0.88 mmol) of 2-(3-pyridinyl)oxazole (Hel. Chim. Acta 1962, 42, 375-381), 175 mg (0.74 mmol) of 2-(6-bromo-2-pyridyl)pyrimidine, 11 mg (0.02 mmol) of [(t-Bu)2P(OH)]2PdCl2 (POPd) and 205 mg (1.48 mmol) of potassium carbonate were initially charged in 5 ml of N,N-dimethylformamide, and the mixture was stirred at 120° C. for 16 hours. For work-up, the reaction mixture was concentrated under reduced pressure and the crude product that remained was purified by chromatography on silica gel (mobile phase: dichloromethane/methanol). This gave 126 mg (54% of theory) of 2-{6-[2-(pyridin-3-yl)-1,3-oxazol-5-yl]pyridin-2-yl}pyrimidine.

후처리

  1. concentrationFor work-up, the reaction mixture was concentrated under reduced pressure
  2. customthe crude product that remained was purified by chromatography on silica gel (mobile phase: dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-0367dad47776491fb64b504a490e7b94
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09173396B2

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